eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia
نویسندگان
چکیده
منابع مشابه
Genetic Relationship between Schizophrenia and Nicotine Dependence
It is well known that most schizophrenia patients smoke cigarettes. There are different hypotheses postulating the underlying mechanisms of this comorbidity. We used summary statistics from large meta-analyses of plasma cotinine concentration (COT), Fagerström test for nicotine dependence (FTND) and schizophrenia to examine the genetic relationship between these traits. We found that schizophre...
متن کاملNicotine dependence and illness severity in schizophrenia.
BACKGROUND Reasons for the increased prevalence of cigarette smoking in schizophrenia are unclear. Studies assessing clinical symptoms have sampled heterogeneous populations, with discrepant findings. AIMS To examine the relationship between clinical features, social adjustment and nicotine dependence in a geographically defined population of people with schizophrenia. METHOD Cross-sectiona...
متن کاملSusceptibility to Smoking and Nicotine Dependence in Schizophrenia
Title of Document: SUSCEPTIBILITY TO SMOKING AND NICOTINE DEPENDENCE IN SCHIZOPHRENIA Alice M. Saperstein, Ph.D., 2009 Directed By: Professor Jack J. Blanchard, Psychology Evidence suggests that high nicotine dependence observed in schizophrenia is related to its core neuronal deficits such as abnormalities in neural synchronization and sensory gating. Some of these neuronal deficits are shown ...
متن کاملVariants in nicotinic receptors and risk for nicotine dependence.
OBJECTIVE A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly investigate the role of genetic variati...
متن کاملNicotine dependence in Croatian male inpatients with schizophrenia
BACKGROUND Patients with schizophrenia have the highest known rates of cigarette smoking, but less is known about their smoking behavior and the differences across geographical regions, including Croatia. The aim of this study was to compare patterns of nicotine dependence between patients with schizophrenia and healthy individuals, and to determine the relationship between clinical presentatio...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2017
ISSN: 1336-0345
DOI: 10.4149/bll_2017_090